Research Paper Volume 13, Issue 2 pp 1842—1858

Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma


Figure 5. Functional enrichment analysis of genes related to DAPK1 in ccRCC tissues. (AC) GO enrichment analysis shows the biological processes, molecular functions and cellular components that represent genes that negatively correlate with DAPK1 expression based on the transcriptome analysis of the TCGA-KIRC dataset. (D) GSEA show that genes upregulated because of DAPK1 downregulation in ccRCC include those that promote metastasis, drug resistance, hypoxia, and invasiveness. Note: ***p<0.001, **p<0.01, *p<0.05.