Research Paper Volume 13, Issue 1 pp 228—240

Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis

Downregulation of miR-155-5p enhances the inhibitory effect of cetuximab on the migration and invasion of TNBC cells. (A, B) EGFR-overexpressed MDA-MB-468 cells were treated with cetuximab (10 nM) and/or the miR-155-5p antagomir (10 nM) for 48 h. Cell migration was detected using the wound healing assay. (C, D) EGFR-overexpressed MDA-MB-468 cells were treated with cetuximab (10 nM) and/or the miR-155-5p antagomir (10 nM) for 24 h. Cell invasion was detected using the transwell invasion assay. *P ##P

Figure 4. Downregulation of miR-155-5p enhances the inhibitory effect of cetuximab on the migration and invasion of TNBC cells. (A, B) EGFR-overexpressed MDA-MB-468 cells were treated with cetuximab (10 nM) and/or the miR-155-5p antagomir (10 nM) for 48 h. Cell migration was detected using the wound healing assay. (C, D) EGFR-overexpressed MDA-MB-468 cells were treated with cetuximab (10 nM) and/or the miR-155-5p antagomir (10 nM) for 24 h. Cell invasion was detected using the transwell invasion assay. *P < 0.05, **P < 0.01 compared with the control group. ##P < 0.01 compared with the cetuximab 10 nM group.