Research Paper Volume 12, Issue 18 pp 18343—18362

Modeling mtDNA hypermethylation vicious circle mediating Aβ-induced endothelial damage memory in HCMEC/D3 cell

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Figure 9. (A) The effect of AKG supplement on delaying the formation of cerebrovascular endothelial cell damage memory formation. (B) The effect of decitabine on delaying the formation of cerebrovascular endothelial cell damage memory formation. (C) Summary of the effect of decitabine and AKG supplement on delaying the formation of cerebrovascular endothelial cell damage memory formation. (D) Experimental protocol for evaluating the effect of AKG supplement on delaying the formation of cerebrovascular endothelial cell damage memory. (E) Experimental protocol for evaluating the effect of decitabine on delaying the formation of cerebrovascular endothelial cell damage memory.