Research Paper Volume 12, Issue 16 pp 16437—16456

Figure 4. The upregulation of KCNN4 served as a prognostic and diagnostic biomarker in PTC. (A) ROC curve analysis demonstrated that KCNN4 could distinguish PTC from nontumorous tissues in TCGA, GSE58689 and our validated cohort. (B) Diagnostic value of KCNN4 expression for the T stage in TCGA. (C, D) ROC curve analysis depicting KCNN4 expression against the N stage and tumor stage in TCGA and our validated cohort. (E, F) Kaplan-Meier analyses of disease-free survival based on low and high KCNN4 expression in PTC patients and the BRAF-like group from TCGA. (G) KCNN4 expression was associated with immune infiltration in TCGA. THCA: Thyroid carcinoma; Cor: Correlation.