Research Paper Volume 13, Issue 6 pp 9119—9134

Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4

Circ

Figure 7. Circ_0000326 promotes cervical cancer cell migration and invasion by targeting miR-338-3p. (A) Cervical cancer cell migration and invasion in HeLa and SiHa cell lines after miR-338-3p mimic or miR-338-3p inhibitor detected by Transwell assay (× 200). (B) Number of migrating and invasive cells in HeLa and SiHa cell lines after silence of circ_0000326. (C) Western blot analysis of MMP-2 and MMP-9 after treatment with miR-338-3p mimic or miR-338-3p inhibitor. Data were expressed as mean ± standard deviation and the data among multiple groups was analyzed by ANOVA.