Research Paper Volume 12, Issue 18 pp 18396—18414
Elevated serum IL-21 levels are associated with stable immune status in kidney transplant recipients and a mouse model of kidney transplantation
Figure 7. Exogenous IL-21 alters cytokine and IL-21R expression in mice after kidney transplantation. The level of IL-21, IL-2, and IL-4, and IL-10, IL-6, and IL-17A in the peripheral blood (A and B) and spleen (D and E) on day 7 post-transplantation was measured by CBA. (C) Histologic evaluation of IL-21R expression in the spleen of subgroups. Values represent mean (±SEM). *P < 0.05, **P < 0.01, and ***P < 0.001. CBA, cytometric bead array; IL, interleukin; SEM, standard error of the mean.