Research Paper Volume 13, Issue 8 pp 12194—12206

CdSe/ZnS quantum dots exhibited nephrotoxicity through mediating oxidative damage and inflammatory response

CdSe/ZnS QDs induced inflammatory response in mice. (A) The mRNA levels of inflammatory cytokines, including nuclear transcription factor-kB (NF-kB), tumor necrosis factor α (TNF-α), macrophage migration inhibitory factor (MIF), interleukin-2 (IL-2), IL-4, IL-6, IL-8, IL-10, IL-18, IL-1β, C-reactive protein (CRP), transforming growth factor (TGF-β), interferon (INF-γ), cytochrome P450 1A (CYP 1A1) and heat shock protein 70 (HSP70), in kidney tissues of mice after CdSe/ZnS QDs and/or N-acetylcysteine (NAC, antioxidant) injection by qRT-PCR. (B) The protein levels of these inflammatory cytokines by enzyme-linked immunosorbent assay. *P #P

Figure 6. CdSe/ZnS QDs induced inflammatory response in mice. (A) The mRNA levels of inflammatory cytokines, including nuclear transcription factor-kB (NF-kB), tumor necrosis factor α (TNF-α), macrophage migration inhibitory factor (MIF), interleukin-2 (IL-2), IL-4, IL-6, IL-8, IL-10, IL-18, IL-1β, C-reactive protein (CRP), transforming growth factor (TGF-β), interferon (INF-γ), cytochrome P450 1A (CYP 1A1) and heat shock protein 70 (HSP70), in kidney tissues of mice after CdSe/ZnS QDs and/or N-acetylcysteine (NAC, antioxidant) injection by qRT-PCR. (B) The protein levels of these inflammatory cytokines by enzyme-linked immunosorbent assay. *P < 0.05 vs. control group; #P < 0.05 vs. CdSe/ZnS group.