Research Paper Volume 12, Issue 16 pp 16514—16538

Coupled immune stratification and identification of therapeutic candidates in patients with lung adenocarcinoma

Figure 6. Connectivity mapping for the gene signature in C3 immune subtype. (A, B) Connections of C3-driven gene signature with the small molecule compounds (A) and gene knockdown/overexpression (B) were analyzed by querying the CLUE database. Connections were viewed as a heat map ranked by the summary connectivity score. (C) The venn diagram indicating the number of target genes of screened small molecule compounds (enrichment score<-80) and gene knockdown/overexpression (gene knockdown, enrichment score<-80; gene overexpression, enrichment score>80), and the overlap between each set of genes. (D) Descriptions of overlapped gene and their corresponding drugs from screened small molecule compounds. (E) Connections of C3-driven gene signature with screened small molecules and gene knockdown/overexpression were analyzed by querying the CLUE database. Connections were viewed as a heat map with each connectivity score in individual cell line. CP, compounds. KD, knockdown. OE, overexpression.