Research Paper Volume 13, Issue 1 pp 241—261

In situ self-assembly of Au-antimiR-155 nanocomplexes mediates TLR3-dependent apoptosis in hepatocellular carcinoma cells

Schematic representation of Au-antimiR-155 NC-mediated activation of growth inhibitory/pro-apoptotic TLR3 signaling in HepG2 cells. De-repression of miR-155-induced TL3R silencing by Au-antimiR-155 NCs promotes apoptosis via TLR3 activation, NF-κβ transcription, caspase-8 activation, and IL-1β release.

Figure 7. Schematic representation of Au-antimiR-155 NC-mediated activation of growth inhibitory/pro-apoptotic TLR3 signaling in HepG2 cells. De-repression of miR-155-induced TL3R silencing by Au-antimiR-155 NCs promotes apoptosis via TLR3 activation, NF-κβ transcription, caspase-8 activation, and IL-1β release.