Research Paper Volume 12, Issue 18 pp 18453—18475

A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer

Figure 5. The selection of three m6A RNA methylation regulators, and their effect on OC prognosis and clinicopathological characteristics. (A) Cox univariate regression analyses were used to examine the associations between expression of 18 m6A RNA methylation regulators and prognosis. (B, C) The P-value of IGF2BP1, VIRMA and ZC3H13 < 0.1. (D) Heatmap and clinicopathologic features of the three selected m6A RNA methylation regulators. (E) Nomogram for forecasting 1-year, 2-year and 3-year survival of clinically OC patients. The nomogram is used by adding up the points identified on the points scale for each variable. Based on the sum of these points projected on the bottom scales, it is used to predict the likelihood of individual patients surviving for 1-year, 2-year and 3-year. (F) Univariate analysis of the hazard ratios for risk score as independent prognostic elements to anticipate the OS. (G) Multivariate analysis of the hazard ratios for risk score as independent prognostic elements to predict the OS.