Research Paper Volume 13, Issue 8 pp 12224—12238

Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer

The mechanism graph of the regulatory network and function of EED-mediated miR-338-5p methylation. EED methylates miR-338-5p to repress its expression, and upregulates expression of miR-338-5p’s target METTL3. METTL3 modifies CDCP1 mRNA through m6A to promote CDCP1 translation, leading to GC progression.

Figure 7. The mechanism graph of the regulatory network and function of EED-mediated miR-338-5p methylation. EED methylates miR-338-5p to repress its expression, and upregulates expression of miR-338-5p’s target METTL3. METTL3 modifies CDCP1 mRNA through m6A to promote CDCP1 translation, leading to GC progression.