Research Paper Volume 13, Issue 11 pp 15638—15658

Transfer of exosomal microRNA-203-3p from dendritic cells to bone marrow-derived macrophages reduces development of atherosclerosis by downregulating Ctss in mice

The elevation of Ctss and decline of miR-203-3p are identified in AS. (A) The volcanic map of DEGs between from GSE56143 with -log10 logarithm of p value as the abscissa and logFC multiple as the ordinate, and |logFC| > 2 as threshold, where 19 genes are up-regulated and indicated as red, and 7 genes are down-regulated and indicated as green. (B) Protein interaction map of DEGs in which the brighter color indicates the higher core level. (C) Online prediction of miRNAs that target Ctss. (D) miR-203-3p expression in DCexs determined by RT-qPCR. *p vs. the healthy volunteers. Statistical data were measurement data, and described as mean ± standard deviation. The paired t test was used for comparison between two groups. n = 76 for AS patients, while n = 49 for healthy volunteers.

Figure 1. The elevation of Ctss and decline of miR-203-3p are identified in AS. (A) The volcanic map of DEGs between from GSE56143 with -log10 logarithm of p value as the abscissa and logFC multiple as the ordinate, and |logFC| > 2 as threshold, where 19 genes are up-regulated and indicated as red, and 7 genes are down-regulated and indicated as green. (B) Protein interaction map of DEGs in which the brighter color indicates the higher core level. (C) Online prediction of miRNAs that target Ctss. (D) miR-203-3p expression in DCexs determined by RT-qPCR. *p < 0.05 vs. the healthy volunteers. Statistical data were measurement data, and described as mean ± standard deviation. The paired t test was used for comparison between two groups. n = 76 for AS patients, while n = 49 for healthy volunteers.