Research Paper Volume 12, Issue 19 pp 19455—19467
Cancer-testis antigen lactate dehydrogenase C4 in hepatocellular carcinoma: a promising biomarker for early diagnosis, efficacy evaluation and prognosis prediction
Cancer-specific pattern of serum and exosomal LDHC expressions in early-stage HCC determined its diagnostic implication. (A, B) Serum LDHC mRNA levels were significantly elevated in early-stage HCC serum samples compared with healthy individuals. (C) The ROC curve of serum LDHC mRNA for the identification of early-stage HCC. (D, E) Expressions of serum exosomal LDHC were elevated in early-stage HCC cases. (F) The ROC curve of serum exosomal LDHC in the diagnosis of early-stage HCC.