Research Paper Volume 12, Issue 19 pp 19455—19467

Cancer-testis antigen lactate dehydrogenase C4 in hepatocellular carcinoma: a promising biomarker for early diagnosis, efficacy evaluation and prognosis prediction


LDH-C4 expressions in HCC tissues using IHC analysis. (A) LDH-C4 levels were higher in HCC cancerous tissues than those in noncancerous tissues, and testis tissues were utilized as LDH-C4 positive controls (×200). (B) LDH-C4 levels were not significantly correlated with KI-67, p53 and CD34 expressions in HCC tissues. (C) LDH-C4 levels (rating scores) were higher in stage 0-II HCC patients than those in stage III-IV HCC patients. (D) The Kaplan-Meier analysis showed that LDH-C4 was negatively correlated with the prognosis of HCC patients, and higher levels of LDH-C4 implied worse prognosis.