Research Paper Volume 12, Issue 22 pp 22688—22699

Figure 3. Conceptual framework for the Mendelian randomization analysis of glycemic traits and risk of Alzheimer’s disease. The design assumed that the genetic variants are associated with glycemic traits, but not with confounders, and the genetic variants are associated with risk of Alzheimer’s disease only through glycemic traits. SNP, single nucleotide polymorphism.