Research Paper Volume 13, Issue 9 pp 13333—13348

Sevoflurane protects against ischemia-reperfusion injury in mice after total knee arthroplasty via facilitating RASD1-mediated protein kinase A pathway activation

Molecular mechanism underling that Sevoflurane treatment alleviates I/R injury in mice after TKA. In the process of I/R injury in mice after TKA, Sevoflurane treatment could potentially inhibit RASD1 expression to activate PKA pathway, consequently increasing the expression patterns of PCNA and Bcl-2 and decreasing the expression patterns of Bax, cleaved caspase-3, IFN-γ, IL-6 and TNF-α, after which the cell proliferation was promoted and cell apoptosis was impeded, finally resulting in relieved I/R injury in mice after TKA.

Figure 6. Molecular mechanism underling that Sevoflurane treatment alleviates I/R injury in mice after TKA. In the process of I/R injury in mice after TKA, Sevoflurane treatment could potentially inhibit RASD1 expression to activate PKA pathway, consequently increasing the expression patterns of PCNA and Bcl-2 and decreasing the expression patterns of Bax, cleaved caspase-3, IFN-γ, IL-6 and TNF-α, after which the cell proliferation was promoted and cell apoptosis was impeded, finally resulting in relieved I/R injury in mice after TKA.