Research Paper Volume 13, Issue 4 pp 4986—4998

Loss of FBP1 promotes proliferation, migration, and invasion by regulating fatty acid metabolism in esophageal squamous cell carcinoma

Loss of FBP1 promoted ESCC cell proliferation, migration and invasion. (A, B) The impact of FBP1 expression on ESCC cell proliferation as assessed using CCK-8 proliferation. (C) Validation of knockdown of FBP1 in Eca109 cells using shFBP1 transfection. (D, E) The impact of FBP1 expression on ESCC cell invasion was performed using shFBP1 transfection in Eca109 cells. (F, G) The impact of FBP1 expression on ESCC cell migration was performed using shFBP1 transfection in Eca109 cells. (H, I) The impact of FBP1 expression on ESCC cell invasion was determined using shFBP1 transfection in ec9706 cells. (J, K) The impact of FBP1 expression on ESCC cell migration was determined using shFBP1 transfection in ec9706 cells. scale bar= 20μm. Mock, the blank control group. Vector, the blank vector group. shFBP1, FBP1 shRNA vector group. *p

Figure 2. Loss of FBP1 promoted ESCC cell proliferation, migration and invasion. (A, B) The impact of FBP1 expression on ESCC cell proliferation as assessed using CCK-8 proliferation. (C) Validation of knockdown of FBP1 in Eca109 cells using shFBP1 transfection. (D, E) The impact of FBP1 expression on ESCC cell invasion was performed using shFBP1 transfection in Eca109 cells. (F, G) The impact of FBP1 expression on ESCC cell migration was performed using shFBP1 transfection in Eca109 cells. (H, I) The impact of FBP1 expression on ESCC cell invasion was determined using shFBP1 transfection in ec9706 cells. (J, K) The impact of FBP1 expression on ESCC cell migration was determined using shFBP1 transfection in ec9706 cells. scale bar= 20μm. Mock, the blank control group. Vector, the blank vector group. shFBP1, FBP1 shRNA vector group. *p< 0.05, **p< 0.01 VS Mock.