Increased expression of myelin-associated genes in frontal cortex of <i>SNCA</i> overexpressing rats and Parkinson’s disease patients

Thomas Hentrich; Zinah Wassouf; Christine Ehrhardt; Eva Haas; James D. Mills; Eleonora Aronica; Tiago Fleming Outeiro; Jeannette Hübener-Schmid; Olaf Riess; Nicolas Casadei; Julia M. Schulze-Hentrich

doi:doi:10.18632/aging.103935

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Research Paper Volume 12, Issue 19 pp 18889—18906

Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients

SNCA overexpression in rat causes age-dependent gene expression perturbations in frontocortical tissue. (A) Schematic diagram of experimental groups along the genotype (wild-type WT, transgenic TG), and age (5 and 12 months) axis highlighting number of differentially expressed genes (DEGs) between TG and WT rats using indicated significance cut-offs. (B) Composition and relative expression levels of rat and human SNCA transcript isoforms across experimental groups. (C) Overrepresented biological processes among 843 DEGs identified in 5-month-old (left panel) and among 162 DEGs in 12-month-old TG rats (right panel). Top five significant terms, their adjusted p-values, enrichment ratios, and DEG count shown.