Research Paper Volume 12, Issue 18 pp 18676—18692

Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer

Figure 9. Validation of the expression and prognostic significance of MMP14 and PKM2 in pancreatic cancer by tissue microarray. (A) Representative photographs of immunohistochemical features of the stained sections of MMP14 and PKM2 in pancreatic cancer tissues and adjacent normal tissues. (B) Kaplan-Meier survival analysis was used to determine the different overall survival of pancreatic cancer patients with highly stained MMP14 or PKM2 (red) and pancreatic cancer patients with low stained MMP14 or PKM2 (blue). P values were generated from Log-rank test. (C) Contingency graphs showed the number of pancreatic cancer patients with both high MMP14 and PKM2 expression. P values were determined by Chi-square test. (D) Kaplan-Meier plotters demonstrated the different overall survival of pancreatic cancer patients with different expression levels of MMP14 and PKM2.