Research Paper Volume 12, Issue 18 pp 18693—18715

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats

Figure 2. Assessment of renal function after I/R in young and old rats with or without DR exposure. (A) The severity of AKI evaluated by serum creatinine levels 48 h after I/R; (B) The severity of AKI evaluated by blood urea nitrogen levels in serum 48 h after I/R; (C) The renal tissue injury evaluated by NGAL levels in urine 24 h after I/R in young rats; (D) The renal tissue injury evaluated by NGAL levels in urine 24 h after I/R in old rats; (E) The comparison of NGAL levels in the urine of young and old rats 24 h after I/R; (F, G) The increase of proliferation evaluated by PCNA levels in kidney tissue 48 h after I/R in young and old rats; (H, I) PCNA levels in kidney tissue 48 h after I/R in young and old rats exposed to DR diet. *p < 0.05 compared to AL-group, **p < 0.05 compared to AL+I/R-group, ***p < 0.05 compared to young AL+I/R-group. For young AL rats n=5, for young DR rats n=6, for old AL rats n=6, for old DR rats n=6. AL, ad libitum, DR, dietary restriction, I/R, ischemia/reperfusion.