Identification of novel <i>FUS</i> and <i>TARDBP</i> gene mutations in Chinese amyotrophic lateral sclerosis patients with HRM analysis

Feng Wang; Shengyu Fu; Jiafan Lei; Hongchen Wu; Shugui Shi; Kangning Chen; Jun Hu; Xueqing Xu

doi:doi:10.18632/aging.103967

← Back

Research Paper Volume 12, Issue 22 pp 22859—22868

Identification of novel FUS and TARDBP gene mutations in Chinese amyotrophic lateral sclerosis patients with HRM analysis

Figure 2. The pedigree with FUS mutation p. R521H. (A) Results of HRM analysis and direct sequencing of patients. (B) Pedigree of the family. An arrowhead indicates the proband. Patients III2, IV3, IV6, and IV7 shared the same mutation, but they did not appear as ALS phenotypes until now.