Figure 7. TRIB3 deficiency enhances autophagy and impairs the malignant progression of GBM in mice. (A, B) Tumor weight and volume in the sh-NC and sh-TRIB3 or sh-NC+CQ, sh-TRIB3+CQ groups. (C) Histological chemistry staining of Ki-67 and CD34 to measure the proliferation and angiogenesis of GBM cells in the sh-NC and sh-TRIB3 or sh-NC+CQ, sh-TRIB3+CQ groups. (D) Representative mice injected with modified sh-TRIB3- or sh-NC-expressing GBM cells. Downregulation of TRIB3 decreased lung metastases. *p<0.05, **p< 0.01, #p< 0.05 vs. TRIB3 KD + sh-NC.