Research Paper Volume 12, Issue 24 pp 25020—25034

TRIB3 facilitates glioblastoma progression via restraining autophagy

Figure 7. TRIB3 deficiency enhances autophagy and impairs the malignant progression of GBM in mice. (A, B) Tumor weight and volume in the sh-NC and sh-TRIB3 or sh-NC+CQ, sh-TRIB3+CQ groups. (C) Histological chemistry staining of Ki-67 and CD34 to measure the proliferation and angiogenesis of GBM cells in the sh-NC and sh-TRIB3 or sh-NC+CQ, sh-TRIB3+CQ groups. (D) Representative mice injected with modified sh-TRIB3- or sh-NC-expressing GBM cells. Downregulation of TRIB3 decreased lung metastases. *p<0.05, **p< 0.01, #p< 0.05 vs. TRIB3 KD + sh-NC.