Research Paper Volume 12, Issue 20 pp 20684—20701

Comprehensive analysis of cancer hallmarks in cutaneous melanoma and identification of a novel unfolded protein response as a prognostic signature

Figure 2. Differential expression of unfolded protein response related genes (UPRRGs) in cutaneous melanoma tissue samples. (A) Heatmap of the differentially expressed UPRRGs in TCGA dataset. (B) Heatmap of the differentially expressed UPRRGs in GSE3189 dataset. (C) Heatmap of the differentially expressed UPRRGs in GSE15605 dataset. (D) Heatmap of the differentially expressed UPRRGs in GSE46516 dataset. (E) Upset plot of differentially expressed UPRRGs in multiple datasets. The dark bar on the left of drawing represents the amount of each dataset. The dark dots in the matrix at right of drawing represent the intersections of differentially expressed UPRRGs. (F) Forest plots of 5 differentially expressed UPRRGs, among which only TARS and KEDLR3 significantly correlated with OS (Overall survival) in TCGA dataset. *p<0.05; **p<0.01.