Research Paper Volume 12, Issue 21 pp 21809—21836

CCL5-dependent mast cell infiltration into the tumor microenvironment in clear cell renal cell carcinoma patients

Figure 8. High CCL5 expression is associated with immune suppression and adverse survival outcomes in ccRCC. (A) The overall survival (OS) of high- and low-CCL5 expressing ccRCC patients in the TCGA KIRC database as evaluated by the survival and survminer packages is shown. P<0.05 is considered statistically significant. (B) The overall survival of ccRCC patients in the TCGA KIRC database according to high- and low- PBRM1 and CCL5 expression using survminer packages, log-rank tests, and COX regression analysis. (C) Enrichment plots show the status of gene sets belonging to IL6/JAK/STAT3 signaling (yellow), IL2/STAT5 (red), the inflammatory response (green), the IFN-α response (light blue), the IFN-γ response (blue), PI3K/AKT/MTOR signaling (purple), and TNF-α/NFΚB signaling (light red) pathways in the CCL5High group of ccRCC patients.