Figure 8. High CCL5 expression is associated with immune suppression and adverse survival outcomes in ccRCC. (A) The overall survival (OS) of high- and low-CCL5 expressing ccRCC patients in the TCGA KIRC database as evaluated by the survival and survminer packages is shown. P<0.05 is considered statistically significant. (B) The overall survival of ccRCC patients in the TCGA KIRC database according to high- and low- PBRM1 and CCL5 expression using survminer packages, log-rank tests, and COX regression analysis. (C) Enrichment plots show the status of gene sets belonging to IL6/JAK/STAT3 signaling (yellow), IL2/STAT5 (red), the inflammatory response (green), the IFN-α response (light blue), the IFN-γ response (blue), PI3K/AKT/MTOR signaling (purple), and TNF-α/NFΚB signaling (light red) pathways in the CCL5High group of ccRCC patients.