Figure 7. Decreased hippocampal pCamKII, pSynGAP levels, and dendritic spine density following LPS challenge were rescued by roscovitine. (A, B) LPS induced significantly decreased hippocampal pCamKII and pSynGAP levels, which were prevented by roscovitine treatment. (C, D) LPS induced significantly increased hippocampal dendritic spine loss, which was reversed by roscovitine treatment. Data are presented as the mean ± SEM, n = 4, *P < 0.05 vs control group; #P < 0.05 vs LPS group. LPS, lipopolysaccharide.