Research Paper Volume 12, Issue 22 pp 23146—23164

pSynGAP1 disturbance-mediated hippocampal oscillation network impairment might contribute to long-term neurobehavioral abnormities in sepsis survivors

Figure 9. LPS-induced neurobehavioral abnormities were attenuated by roscovitine. (A) LPS had no effect on the total distance traveled, while roscovitine treatment significantly increased total distance traveled in LPS + roscovitine group compared with LPS group. (B) No difference in time spent in the center of the open arena was observed among groups. (C, D) There was no difference in time in the open arms and closed arms between groups. (E) LPS-induced significantly decreased the freezing time to context was reversed by roscovitine treatment. (F) There was no difference in freezing time to tone in the auditory-cued fear test among groups. (G) Decreased preference for sucrose in LPS-exposed mice was reversed by roscovitine treatment. (H) LPS significantly increased immobility compared with control group, which was not prevented by roscovitine treatment. Data are presented as the mean ± SEM, n = 10-12, *P < 0.05 vs control group; #P < 0.05 vs LPS group. LPS, lipopolysaccharide.