Research Paper Volume 12, Issue 24 pp 25101—25119

Could microtubule inhibitors be the best choice of therapy in gastric cancer with high immune activity: mutant DYNC1H1 as a biomarker

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Figure 2.

Validation of microtubule inhibitors (MTIs) in gastric cancer cell lines with high immune activity based on GDSC database. (AC) Plot depicting the correlations of IC50 values of some tubulin related drugs ((A) MTIs, (B) AURK inhibitors, (C) KIF inhibitors) with TMB levels in GC cell lines based on GDSC database using Spearman’s correlation. (DF) Histograms showing the different levels of IC50 values of some tubulin related drugs ((D) MTIs, (E) AURK inhibitors, (F) KIF inhibitors) between MSI-H and MSS/MSI-L GC cell lines based on GDSC database using Student’ s t test. P-value < 0.05 was considered significant.