Research Paper Volume 12, Issue 24 pp 25120—25137

Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways

Figure 5. Impacts of Apelin on PPAR-alpha expression and CVF values in D-IRI rats. (A) Examination for PPAR-alpha expression by immunohistochemistry staining. Magnification, ×200. (B, C) CVF values in D-IRI rats was examined by Masson’s staining. ** P<0.01 represents the values compared to the D-Sham group. #P<0.05 represents the values compared to the Ad-GFP group. Magnification, ×200. CVF: collagen volume fraction; D-Sham: Diabetes sham group; D-IRI: Diabetes ischemia reperfusion injury; Ad-GFP: D-IRI rats injected with Ad-recombined lentiviral vector expressing GFP. Ad-Apelin: D-IRI rats injected with Ad-recombined lentiviral rector expressing Apelin.