Research Paper Volume 12, Issue 24 pp 25138—25152

Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization

Figure 3. BMSC exosomes prevented cartilage destruction in a rat model. (A) Representative images of HE staining in knee sections. Scale bar: 50 μm. (B) Representative images of Safranin O / Fast Green staining in knee sections. Scale bar: 50 μm. (C) Representative adoptive Dil-labelled BMSC-Exos (green fluorescence) in a knee joint. Scale bar: 50 μm (D) Evaluation of cartilage destruction using the OARSI scoring system. *p < 0.05 compared to the Sham group; # p < 0.05 compared to the PBS group.