Research Paper Volume 12, Issue 24 pp 25172—25188

Vascular endothelial growth factor receptor-2 and its association with tumor immune regulatory gene expression in hepatocellular carcinoma

Figure 1. Immune cell infiltration patterns of the two VEGF score subtypes. The high VEGF score subtype showed lower tumor purity, higher stroma fraction, and higher leukocyte fraction (A). Higher immune score, stromal score, and Estimate score based on the ESTIMATE algorithm were observed in the high VEGF score subtype (B). The high VEGF score subtype had relatively higher immune cell infiltration, including cells contributing to both anti-tumor immunity and pro-tumor suppression (C). A positive association between these two categories of immune cells in the local tumor microenvironment was observed in both VEGF score subtypes (D). The high VEGF score subtype showed both higher anti-tumor immunity and pro-tumor suppression (E).