Research Paper Volume 12, Issue 24 pp 25207—25228

Impairment of Pol β-related DNA base-excision repair leads to ovarian aging in mice

Figure 6. Diminished ovarian reserve in Pol β-deficient mice. Mice with BRCA1 (**P <0.01) or BRCA2 (*P <0.05) mutations had significantly lower mean serum AMH concentrations; Pol β+/- mice had significantly lower mean serum AMH concentrations compared to wt mice (**P < 0.01, Student’s t test), similarly to mice with BRCA1 or BRCA2 mutations. All bar graphs show the mean ± SD. (N stands for the number of mice).