Research Paper Volume 12, Issue 24 pp 25229—25255

Exposure to ozone impacted Th1/Th2 imbalance of CD4+ T cells and apoptosis of ASMCs underlying asthmatic progression by activating lncRNA PVT1-miR-15a-5p/miR-29c-3p signaling

Figure 3. Linkage of lncRNA PVT1 expression with Th1/Th2 balance of asthmatic mice. (A) PVT1 expression was monitored within CD4+ T cells that were obtained from mice models of saline+air (SA), saline+ozone (SO), OVA+air (OA) and OVA+ozone (OO) groups. *: P<0.05 when compared with SA group, #: P<0.05 when compared with saline+ozone group, &: P<0.05 when compared with OVA+air group. (B, C) Correlation matrixes were established concerning PVT1 expression and Th1/Th2-specific cytokines in all asthmatic mice (B) and in asthmatic mice managed through 4 approaches (C).