Research Paper Volume 12, Issue 24 pp 25229—25255

Exposure to ozone impacted Th1/Th2 imbalance of CD4+ T cells and apoptosis of ASMCs underlying asthmatic progression by activating lncRNA PVT1-miR-15a-5p/miR-29c-3p signaling

Figure 4. MiRNAs potentially sponged by lncRNA PVT1 within ASMCs and CD4+ T cells. (A) MiR-15a-5p, miR-140-5p, miR-20b-5p, miR-488-3p and miR-455-5p were differentially expressed within CD4+ T cells of saline+air, saline+ozone, OVA+air and OVA+ozone groups. *: P<0.05 when compared with SA group, #: P<0.05 when compared with saline+ozone group, &: P<0.05 when compared with OVA+air group. (B) Expressions of miR-29c-3p, miR-143-3p, miR-511-3p, miR-497-5p and miR-488-3p were evaluated within ASMCs of mice models among saline+air, saline+ozone, OVA+air and OVA+ozone groups. *: P<0.05 when compared with SA group, #: P<0.05 when compared with saline+ozone group, &: P<0.05 when compared with OVA+air group. (C) MiR-15a-5p and miR-20b-5p were sponged and regulated by lncRNA PVT1 in CD4+ T cells. (D) MiR-29c-3p, miR-143-3p and miR-511-3p were subjected to sponged modulation by lncRNA PVT1 in ASMCs.