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Research Paper Volume 12, Issue 24 pp 25229—25255

Exposure to ozone impacted Th1/Th2 imbalance of CD4+ T cells and apoptosis of ASMCs underlying asthmatic progression by activating lncRNA PVT1-miR-15a-5p/miR-29c-3p signaling

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Figure 6. The effects of PVT1 and miR-29c-3p on proliferation and apoptosis of ASMCs. (A) PVT1 expression in ASMCs was determined after transfection of pcDNA-PVT1 and si-PVT1. *: P<0.05 when compared with NC group. (B–D) The viability (B), proliferation (C) and apoptosis (D) of ASMCs were compared after transfections of pcDNA-PVT1 and si-PVT1. *: P<0.05 when compared with NC group. (E) The expressions of apoptotic proteins within ASMCs were compared under treatments of pcDNA-PVT1and si-PVT1. *: P<0.05 when compared with NC group. (F–H) The viability (F), proliferation (G) and apoptosis (H) of ASMCs were evaluated among pcDNA3.1, pcDNA3.1-PVT1 and pcDNA3.1-PVT1+miR-29c-3p mimic groups. *: P<0.05 when compared with pcDNA3.1 group, #: P<0.05 when compared with pcDNA3.1-PVT1 group. (I) Expressions of apoptins were measured within ASMCs of pcDNA3.1, pcDNA3.1-PVT1 and pcDNA3.1-PVT1+miR-29c-3p mimic groups. *: P<0.05 when compared with pcDNA3.1 group, #: P<0.05 when compared with pcDNA3.1-PVT1 group.