Research Paper Volume 12, Issue 24 pp 25452—25468

Sevoflurane postconditioning reduces myocardial ischemia reperfusion injury-induced necroptosis by up-regulation of OGT-mediated O-GlcNAcylated RIPK3

Figure 5. OSMI-1 eliminated SPC-mediated decreases in cardiac infarction and the LDH level. (A) Infarct size was determined by using 1%TTC staining. Represetnative images were shown. (B) Infarct size was expressed as a percentage of area at risk. n=6/group. (C) Myocardial necroptosis marker enzyme LDH level in all groups. OSMI-1, the OGT inhibitor; DMSO, the OSMI-1 solvent. n=6/group. The columns and errors bars represent means ± SD. * P < 0.05 vs. SHAM group; # P < 0.05 vs. IR group; & P < 0.05 vs. SPC group.