Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits

Yu Wang; Yunxiao Kang; Chunxiao Qi; Tianyun Zhang; Hui Zhao; Xiaoming Ji; Wensheng Yan; Yuanxiang Huang; Rui Cui; Guoliang Zhang; Geming Shi

doi:doi:10.18632/aging.104155

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Research Paper Volume 12, Issue 24 pp 25487—25504

Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits

Figure 4. Effects of PTX treatment on brain oxidative balance in aged rats. (A, B) Effects of PTX treatment on MDA levels in the SN and HIPP of aged rats. (C, D) Effects of PTX treatment on GSH/GSSG ratio in the SN and HIPP of aged rats. Data are expressed as the mean ± S.D. (n=6 rats/group). *P<0.05 versus 6Mon rats, **P<0.01 versus 6Mon rats, ^#P<0.01 versus 24Mon rats.