Research Paper Volume 12, Issue 24 pp 25528—25546

miRNA-122-5p stimulates the proliferation and DNA synthesis and inhibits the early apoptosis of human spermatogonial stem cells by targeting CBL and competing with lncRNA CASC7

Figure 6. Differentially expressed LncRNAs in human spermatogonia between OA and NOA patients. (A) The cluster heat map showed lncRNAs with an expression change fold ≥2 from microarray data (p<0.025) in human spermatogonia from OA patients compared with NOA patients. (B) Scatter plot illustrated the differentially expressed lncRNAs with an expression change fold ≥2 (p<0.025) in human spermatogonia from OA patients compared with NOA patients. (C–F) Real-time qPCR revealed the different expression levels of XIST, CDKN2B-AS1, MAL2 and CASC7 in human spermatogonia between OA and NOA patients. * denoted statistically significant differences (p< 0.05) in human spermatogonia between human OA and NOA patients.