Research Paper Volume 12, Issue 24 pp 25658—25672

Up-regulation of circRNA-0003528 promotes mycobacterium tuberculosis associated macrophage polarization via down-regulating miR-224-5p, miR-324-5p and miR-488-5p and up-regulating CTLA4

Figure 5. The hsa_circ_0003528 signaling pathway was associated with macrophage polarization induced by IFN-γ + LPS or IL-4 (*P value < 0.05 vs. M (-) group; ** P value < 0.05 vs. M(IFN-γ + LPS) group). (A) The expression of hsa_circ_0003528 in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (B) The expression of miR-224-5p in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (C) The expression of miR-324-5p in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (D) The expression of miR-488-5p in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group; (E) The expression of CTLA4 mRNA in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group. (F) The expression of CTLA4 protein in the M(-) group, M(IFN-γ + LPS) group and M(IL-4) group.