Research Paper Volume 12, Issue 24 pp 25658—25672

Up-regulation of circRNA-0003528 promotes mycobacterium tuberculosis associated macrophage polarization via down-regulating miR-224-5p, miR-324-5p and miR-488-5p and up-regulating CTLA4

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Figure 7.

Effect of overexpression of hsa_circ_0003528 on cells undergoing macrophages polarization induced by IFN-γ + LPS (Group 1: M(IFN-γ + LPS), pcDNA; Group 2: M(IFN-γ + LPS), pcDNA-circ_0003528; Group 3: M(IFN-γ + LPS), pcDNA-circ_0003528, NC siRNA; Group 4: M(IFN-γ + LPS), pcDNA-circ_0003528, circ_0003528 siRNA; * P value < 0.05 vs. Group 1; ** P value < 0.05 vs. Group 3). (A) Fold change of circ_0003528 expression in four THP-1 cell groups; (B) Fold change of CLCL10 expression in four THP-1 cell groups; (C) Fold change of CLCL11 expression in four THP-1 cell groups; (D) Fold change of Nos2 expression in four THP-1 cell groups; (E) Fold change of CCL17 expression in four THP-1 cell groups; (F) Fold change of CCL18 expression in four THP-1 cell groups.