Research Paper Volume 12, Issue 24 pp 25658—25672

Up-regulation of circRNA-0003528 promotes mycobacterium tuberculosis associated macrophage polarization via down-regulating miR-224-5p, miR-324-5p and miR-488-5p and up-regulating CTLA4

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Figure 8.

Effect of overexpression of hsa_circ_0003528 on production of inflammatory cytokines induced by IFN-γ + LPS (Group 1: M(IFN-γ + LPS), pcDNA; Group 2: M(IFN-γ + LPS), pcDNA-circ_0003528; Group 3: M(IFN-γ + LPS), pcDNA-circ_0003528, NC siRNA; Group 4: M(IFN-γ + LPS), pcDNA-circ_0003528, circ_0003528 siRNA; * P value < 0.05 vs. Group 1; ** P value < 0.05 vs. Group 3). (A) Concentration of TNF-α in four THP-1 cell groups; (B) Concentration of IL-6 in four THP-1 cell groups; (C) Concentration of IL-12 in four THP-1 cell groups; (D) Concentration of IL-10 in four THP-1 cell groups; (E) Concentration of CCL17 in four THP-1 cell groups; (F) Concentration of CCL18 in four THP-1 cell groups; (G) Concentration of CCL22 in four THP-1 cell groups.