Research Paper Volume 12, Issue 24 pp 25700—25717

Inhibition of PAR-1 delays aging via activating AMPK in C. elegans

Figure 1. Inhibition of par-1 during adulthood is sufficient to significantly extend lifespan. (A) Survival curves of the wild-type N2 and par-1(zu310) temperature sensitive mutant (p < 0.0001, log-rank test). (B) Survival curves of the wild-type N2 treated with either the control RNAi or par-1 RNAi at different stages. Dev, par-1 RNAi treatment during development (p = 0.5368, log-rank test). AD, par-1 RNAi treatment during adulthood (p < 0.0001, log-rank test). Dev + AD, par-1 RNAi treatment during the whole life (p < 0.0001, log-rank test). Detailed quantitative data and statistical analyses are included in Supplementary Table 1.