Research Paper Volume 12, Issue 24 pp 24604—24622

Control of lifespan and survival by Drosophila NF-κB signaling through neuroendocrine cells and neuroblasts

Figure 1. Pan-neuronal activation of Toll or Imd pathway signaling shortens lifespan. (AD) Survival, median lifespan, and 10% max lifespan (A) and bodyweight (B) of elav-Gal4/UAS-CactusRNAi males (blue) and UAS-CactusRNAi/+ (black) control males. Corresponding lifespan analysis (C) and bodyweight (D) for females. (EH) Survival, median lifespan, and 10% max lifespan (E) and bodyweight (F) of elav-Gal4/UAS-Dif males (blue) and UAS-Dif/+ (black) control males. Corresponding lifespan analysis (G) and bodyweight (H) for females. (IL) Survival, median lifespan, and 10% max lifespan (I) and bodyweight (J) of UAS-Relish/+;elav-Gal4/+ males (blue) and UAS-Relish/+;+/+ (black) control males. Corresponding lifespan analysis (K) and bodyweight (L) for females. Data information: statistics for curve comparisons are shown in the figure. Error bars represent mean ± SEM. **** p<.0001 (log-rank test). n = at least 100 flies for each genotype in lifespan experiments. n = 4 vials of 15 flies for each genotype for bodyweight measurements.