Research Paper Volume 13, Issue 1 pp 411—423

The improved anticancer effects of Bortezomib-loaded hollow mesoporous silica nanospheres on lymphoma development

BTZ@HMSNs augments cell death of lymphoma. (A) Live/dead staining detection for SNK-1 cells treated with PBS (control), HMSNs, BTZ (75 nM), BTZ@HMSNs (containing 75 nM of BTZ). Scale bar equals 5 nm. (B) Cell apoptosis rate of SNK-1 cells treated with PBS (control), HMSNs, BTZ, BTZ@HMSNs by flow cytometry analysis. (C) The expression of apoptosis-related proteins (Bcl-2, Bax, and cleaved-caspase-3) in SNK-1 cells treated with PBS (control), HMSNs, BTZ, BTZ@HMSNs by western blotting. BTZ, bortezomib; HMSNs, hollow mesoporous silica nanospheres. The differences between groups were analyzed by one-way ANOVA followed by multiple comparison with Tukey test. *P P

Figure 3. BTZ@HMSNs augments cell death of lymphoma. (A) Live/dead staining detection for SNK-1 cells treated with PBS (control), HMSNs, BTZ (75 nM), BTZ@HMSNs (containing 75 nM of BTZ). Scale bar equals 5 nm. (B) Cell apoptosis rate of SNK-1 cells treated with PBS (control), HMSNs, BTZ, BTZ@HMSNs by flow cytometry analysis. (C) The expression of apoptosis-related proteins (Bcl-2, Bax, and cleaved-caspase-3) in SNK-1 cells treated with PBS (control), HMSNs, BTZ, BTZ@HMSNs by western blotting. BTZ, bortezomib; HMSNs, hollow mesoporous silica nanospheres. The differences between groups were analyzed by one-way ANOVA followed by multiple comparison with Tukey test. *P < 0.05 and **P < 0.01. Values are means ± SD.