Figure 5. The mRNA levels of Src homology 1 domain-containing protein tyrosine phosphatase (SHP-1), c-Kit, nuclear factor-κB (NF-κB), and JAK1 in SNK-1 cells treated with PBS (control), HMSNs, BTZ (75 nM), BTZ@HMSNs (containing 75 nM of BTZ) by RT-PCR. BTZ, bortezomib; HMSNs, hollow mesoporous silica nanospheres. The differences between groups were analyzed by one-way ANOVA followed by multiple comparison with Tukey test. *P < 0.05 and **P < 0.01. Values are means ± SD.