ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials, and the World Health Organization International Clinical Trials Registry Platform, and international registers for published and unpublished double-blind randomized controlled trials from database inception to July 20, 2019. The pooled estimates of hazard ratios (HR) with 95% credible intervals (CrIs) were calculated for PFS, OS, and the time to deterioration of quality of life (QoL). The pooled estimates of odds ratio (OR) with 95% CrIs were calculated for ORR, AEs, and treatment discontinuation. This study is registered with PROSPERO (CRD42019138939)." name="description">
Figure 7. Forest plots comparing any-grade and grade 3–4 non-hematological/any AEs. (A) Grade 3–4 fatigue; (B) any-grade fatigue; (C) grade 3–4 headache; (D) any-grade headache.