Research Paper Volume 13, Issue 1 pp 525—536

Liraglutide improved the cognitive function of diabetic mice via the receptor of advanced glycation end products down-regulation

Liraglutide restored RAGE and GLP-1R of db/db mice in hippocampus. "*" significant difference between db/db mice and db/m mice; "#" significant difference between db/db mice with liraglutide and db/db mice without liraglutide; "db/m" of (A) db/m mice without liraglutide; "db/db" of (A) db/db mice without liraglutide; "db/db + L" of (A) db/db mice with liraglutide at a concentration of 240ug/Kg; "1" of (B–D) db/m mice without liraglutide; "2" of (B–D) db/db mice without liraglutide; "3" of (B–D) db/db mice with liraglutide at a concentration of 240ug/Kg.

Figure 2. Liraglutide restored RAGE and GLP-1R of db/db mice in hippocampus. "*" significant difference between db/db mice and db/m mice; "#" significant difference between db/db mice with liraglutide and db/db mice without liraglutide; "db/m" of (A) db/m mice without liraglutide; "db/db" of (A) db/db mice without liraglutide; "db/db + L" of (A) db/db mice with liraglutide at a concentration of 240ug/Kg; "1" of (B–D) db/m mice without liraglutide; "2" of (B–D) db/db mice without liraglutide; "3" of (B–D) db/db mice with liraglutide at a concentration of 240ug/Kg.