Research Paper Volume 13, Issue 1 pp 555—577

Autophagy-mediated regulation patterns contribute to the alterations of the immune microenvironment in periodontitis

The correlation between infiltrating immunocytes and autophagy genes. (A) The difference in the abundance of each immune microenvironment infiltrating cells between healthy and periodontitis samples. (B) The dot-plot demonstrated the correlations between each dysregulated immune microenvironment infiltration cell type and each dysregulated autophagy genes. (C) The most positive correlated immunocyte-autophagy gene pairs are EDEM1-Activated B cell and the expression status or fraction status are presented by violin-plot at the left panel, indicating a higher expression of EDEM1 and a higher fraction of Activated B cell were found in periodontitis. (D) The most negatively correlated immunocyte-autophagy gene pairs are NCKAP1-Monocyte and the expression status or fraction status are presented by violin-plot at the right panel, indicating there is a lower expression of NCKAP1 in periodontitis and a higher level of the monocyte population.

Figure 3. The correlation between infiltrating immunocytes and autophagy genes. (A) The difference in the abundance of each immune microenvironment infiltrating cells between healthy and periodontitis samples. (B) The dot-plot demonstrated the correlations between each dysregulated immune microenvironment infiltration cell type and each dysregulated autophagy genes. (C) The most positive correlated immunocyte-autophagy gene pairs are EDEM1-Activated B cell and the expression status or fraction status are presented by violin-plot at the left panel, indicating a higher expression of EDEM1 and a higher fraction of Activated B cell were found in periodontitis. (D) The most negatively correlated immunocyte-autophagy gene pairs are NCKAP1-Monocyte and the expression status or fraction status are presented by violin-plot at the right panel, indicating there is a lower expression of NCKAP1 in periodontitis and a higher level of the monocyte population.