Research Paper Volume 13, Issue 1 pp 555—577

Autophagy-mediated regulation patterns contribute to the alterations of the immune microenvironment in periodontitis

Gens and gene modules related to autophagy-mediated patterns (A) The sample clustering was based on the expression data of all samples. The top 25% of variation genes were used for the analysis by WGCNA and outlier samples were excluded. (B) Gene dendrogram obtained by average linkage hierarchical clustering. The color row underneath the dendrogram shows the module assignment determined by the Dynamic Tree Cut, in which 16 modules were identified. (C) Heatmap of the correlation between module eigengenes and the autophagy-mediated regulation patterns. (D) A scatterplot of gene significance (GS) for autophagy-mediated pattern-2 versus module membership (MM) in the brown module. GS and MM exhibit a very significant correlation, implying that hub genes of the green module also tend to be highly correlated with autophagy-mediated regulation pattern-2.

Figure 9. Gens and gene modules related to autophagy-mediated patterns (A) The sample clustering was based on the expression data of all samples. The top 25% of variation genes were used for the analysis by WGCNA and outlier samples were excluded. (B) Gene dendrogram obtained by average linkage hierarchical clustering. The color row underneath the dendrogram shows the module assignment determined by the Dynamic Tree Cut, in which 16 modules were identified. (C) Heatmap of the correlation between module eigengenes and the autophagy-mediated regulation patterns. (D) A scatterplot of gene significance (GS) for autophagy-mediated pattern-2 versus module membership (MM) in the brown module. GS and MM exhibit a very significant correlation, implying that hub genes of the green module also tend to be highly correlated with autophagy-mediated regulation pattern-2.