Figure 2. The A3R agonist ameliorated neuronal apoptosis and improved neurobehavioral outcomes by regulating neuroinflammatory after SAH. (A) Apoptotic neurons and percentage of TUNEL-positive cells in the cerebral cortex 24 h after SAH. NeuN was used as a neuron marker. (B) Neurologic score was performed 24 h after SAH. (C, D) The changes of IL-1β, TNF-α, IL-4 and IL-10 mRNA at 6 h, 12 h and 24 h after SAH. (E, F) The inflammatory cytokines was measured by enzyme-linked immunosorbent assay at 24 h after SAH. n=5 in each group. Values are shown as the mean ± SD. *p < 0.05 and **p < 0.01, versus sham group; ## p < 0.01, versus SAH group; & p < 0.05 and && p < 0.01 versus SAH+CI-IB-MECA group.