Research Paper Volume 13, Issue 1 pp 714—734

Identification of “regulation of RhoA activity panel” as a prognostic and predictive biomarker for gastric cancer

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Figure 4.

Association of RRAP with immune-related biomarkers. (A) Boxplot for differences in the tumor mutational burden (TMB) between RRAP-wild type and RRAP-mutant tumors in the TCGA training, TCGA validation, and CGC cohorts. (B) Boxplot for differences in the neoantigens between RRAP-wild type and RRAP-mutant tumors in the CGC cohort. (C) Boxplot for differences in the dMMR percentage between RRAP-wild type and RRAP-mutant tumors in TCGA training, TCGA validation, and CGC cohort. The Wilcox rank-sum test was applied to compare the differences. (D) Association of overall survival and TMB, neoantigen burden (NAB), and dMMR in the 3 cohorts. The hazard ratio was estimated with univariate Cox analysis, and the log-rank test was applied to calculate the p-value.